IGF1, IGFBP1, and IGFBP3 genes and mammographic density: The Multiethnic Cohort
نویسندگان
چکیده
منابع مشابه
Mammographic density and breast cancer risk: the multiethnic cohort study.
In a nested case-control study (2001-2004), the authors investigated the association between mammographic density and breast cancer risk among women of Caucasian, Japanese, and Native Hawaiian ancestry in the Hawaii component of the Multiethnic Cohort Study. The authors retrieved several prediagnostic mammograms for breast cancer cases and for controls frequency-matched to cases by age and ethn...
متن کاملHaplotype-based association studies of IGFBP1 and IGFBP3 with prostate and breast cancer risk: the multiethnic cohort.
Collective evidence suggests that the insulin-like growth factor (IGF) system plays a role in prostate and breast cancer risk. IGF-binding proteins (IGFBP) are the principal regulatory molecules that modulate IGF-I bioavailability in the circulation and tissues. To examine whether inherited differences in the IGFBP1 and IGFBP3 genes influence prostate and breast cancer susceptibility, we conduc...
متن کاملA longitudinal investigation of mammographic density: the multiethnic cohort.
Mammographic densities are hypothesized to reflect the cumulative exposure to risk factors that influence breast cancer incidence. This report analyzed percent densities over time and explored predictors of density change in relation to age. The study population consisted of 607 breast cancer cases and 667 frequency matched controls with 1,956 and 1,619 mammographic readings, respectively. Mamm...
متن کاملCommon genetic variation in IGF1, IGFBP1 and IGFBP3 and ovarian cancer risk.
Insulin-like growth factor (IGF) 1 and its binding proteins foster cellular proliferation and inhibit apoptosis. In vitro studies show that IGF1 increases ovarian cell growth and invasive potential, suggesting a role for the IGF1 pathway in ovarian cancer etiology. We evaluated genetic variation in the IGF1, IGFBP1 and IGFBP3 genes in relation to ovarian cancer risk by genotyping 29 haplotype-t...
متن کاملIGF1 and IGFBP3 polymorphisms and plasma levels in women.
To the Editor: D'Aloisio et al. report on IGF1 and IGFBP3 polymorphisms in relation to circulating insulinlike growth factor I (IGF-I) and insulin like growth factor binding protein-3 (IGFBP-3) plasma levels among African American and Caucasian women (CEBP 2009;18:954–66). In their study, mean IGF-I levels among Caucasian and African American were comparable. This is surprising because the Cauc...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2009
ISSN: 0020-7136,1097-0215
DOI: 10.1002/ijc.25142